Overall, my experience is listening to different active setups. I have not heard genelecs but some other equally regarded ones. If the definition of high end is the following; complete absence of electronic artifacts , the musicians in the room performing for you , absolute neutrality with correct tone and timbre --------- then these all one box speakers do not do it for me. I am not saying they are bad. They sound very good. And they will beat similarly priced passive setups in many parameters. But they fall apart when you compare to the really high end active setups and passive.
Now I am keeping this very open. If I hear an all in one box which I like and I am unable to hear a different variety which comes close to the all in one box, I will be a convert for sure. Only time can say
Some problems you listed are compromises found in mid & low quality systems to keep the price down. The top brands have figured out how to overcome all the problems you have described and have all stages perfecty designed in their premium active loudspeaker models. The so called all-in-one design thats done perfectly, keeps all the stages in the designers control and is designed to be immune to all matching, mating and synchronizing problems of the various separate stages leading to an extreme performance standard that is as good as it can get.
Pandamaudio recently organized some interesting Genelec DSP demos in Bombay & Madras which you can read about in AV Lounge. He plans to do a presentation in Bangalore & Delhi soon and will invite youll to listen. Hope you become a convert after you hear that dsp active loudspeaker system play